Alice, Nellie and Howard Pitzel were victims of H. H. Holmes. They were kids of Benjamin Pitzel who was also killed by Holmes.
Alice was the first kid who had joined Holmes to look for her father in Philadelphia. Later, Holmes will take Nellie and Howard from Mrs. Pitzel, convincing her that he wants all kids to join their father.
He traveled with them through America, until one day when all the kids disappeared.
Investigation showed that Holmes had killed Howard in small cottage in Irvington, Indianapolis, and Alice and Nellie had met their deaths at St. Vincent Street in Toronto.